FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HDAC3I
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General Information
Symbol
Dmel\HDAC3I
Species
D. melanogaster
Name
FlyBase ID
FBal0245124
Feature type
allele
Associated gene
Dmel\HDAC3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhu et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: G158D.

(Zhu et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:5,473,720..5,473,720 [-]
Nucleotide change:

G5473720A

Amino acid change:

G158D | HDAC3-PA

Reported amino acid change:

G158D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transheterozygous Hdac3I/Hdac3J wandering third instar larvae exhibit imaginal discs that are significantly reduced in size compared to wildtype. The pouch region of the wing disc appears particularly small and quantitative measurements reveal reductions to about 30% of normal size. These wing discs display robust and widespread apoptosis. In general this is more prominent in the wing blade versus the notal portion of the disc and the precise pattern of apoptotic cells can vary considerably from disc to disc. Cell proliferation appears unaffected.

      (Zhu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Hdac3I leads to moderate suppression of the eye colour variegation found in In(1)wm4 mutants.

      (Zhu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HDAC3I
      Hdac3I
      hdac3I
      (Zhu et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)