Loss of sumoylation in blood cells and the fat body through expression of lwr^JF01386 under the control of Scer\GAL4^Cg.PA leads to hyperactive immunity with blood cells infiltrating the fat body upon L.victoriae parasitic wasp infection.

Knock-down of lwr^JF01386 in the fat body (under the control of Scer\GAL4^Lsp2.PH does not yield strong fat body defects such as loss of tissue integrity but results in a weak but reproducible differentiation and aggregation of blood cells in the hemocoel. In contrast expression in blood cells and the fat body under the control of Scer\GAL4^Cg.PA or in the hemocoel alone under the control of Scer\GAL4^Hml.PG significantly promotes infiltration and tumorigenesis upon L.victoriae parasitic wasp infection. Approximately 60% of Scer\GAL4^Cg.PA>lwr^JF01386 animals develop microtumors whereas parental genotypes are not tumorous in third-instar larval stages.