FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\VhlYH.UAS.Tag:HA
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General Information
Symbol
Dmel\VhlYH.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0246019
Feature type
allele
Associated gene
Dmel\Vhl
Associated Insertion(s)
Carried in Construct
P{UAS-Vhl.YH}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Duchi et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Duchi et al., 2010)
Mutagen
in vitro construct
(Duchi et al., 2010, Hsouna et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Vhl.YH}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Vhl which contains the amino acid replacement Y51H and which is tagged at the C-terminal end with three copies of Tag:HA.

(Duchi et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Vhl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,280,028..11,280,028 [+]
Nucleotide change:

T11280028C

Amino acid change:

Y51H | Vhl-PA; Y51H | Vhl-PB

Reported amino acid change:

Y51H

Comment:

Analogous Y98H mutation in human VHL implicated in von Hippel-Lindau syndrome; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Duchi et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  von Hippel-Lindau disease
      CEA with Vhl1
      (Duchi et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Duchi et al., 2010)
      VHL:p.Tyr98His
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: VHL_2223
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4btl.PS/VhlYH.UAS.Tag:HA fails to rescue VhlRNAi.UAS

      (Hsouna et al., 2010)
      Comments

      The mutant tracheal phenotypes (ectopic migration and abnormal lumen) seen in embryos expressing VhldsRNA.Scer\UAS under the control of Scer\GAL4btl.PS are not rescued by co-expression of VhlYH.Scer\UAS.T:Ivir\HA1.

      (Hsouna et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      VhlYH.Scer\UAS.T:Ivir\HA1
      VhlYH.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)