FB2026_02 , released June 18, 2026
Allele: Dmel\DysDp186.30.3
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General Information
Symbol
Dmel\DysDp186.30.3
Species
D. melanogaster
Name
FlyBase ID
FBal0246199
Feature type
allele
Associated gene
Dmel\Dys
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Fradkin et al., 2008)
Progenitor genotype
DysGE20705
(Fradkin et al., 2008)
Cytology
Description

Imprecise excision of P{EP}DysGE20705 generates a 0.9kb deletion removing the Dp186 ATG codon and most of the unique first exon of Dp186.

(Fradkin et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Voltage-clamp recordings from either the aCC or RP2 motor neurons reveals that synaptic currents are significantly increased in amplitude in DysDp186.30.3 mutants.

      The frequency of action potential-dependent synaptic currents recorded in aCC/RP2 is not significantly altered in DysDp186.30.3 mutants compared to wild-type.

      The presence of TTX has no effect on the ampltiude of miniature synaptic currents (mEPSCs) in aCC/RP2 neurons in DysDp186.30.3 mutants. The frequency is, however, signficantly increased compared to controls, indicating a heightened probability of presynaptic vesicle release.

      (Fradkin et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DysDp186.30.3
      (Fradkin et al., 2008)
      Dys<up>Dp186 30.3</up>
      (Jantrapirom et al., 2019)
      DysDp186.30.3
      Name Synonyms
      Secondary FlyBase IDs
        References (2)