FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PANK2m.UAS
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General Information
Symbol
Hsap\PANK2m.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0246212
Feature type
allele
Associated gene
Hsap\PANK2
Associated Insertion(s)
Carried in Construct
P{UAS-PANK2.m}
Key Links
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
in vitro construct
(Wu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-PANK2.m}
Cytology
Description

UAS regulatory sequences drive expression of an isoform of Hsap\PANK2 containing a putative mitochondrial target sequence.

(Wu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\PANK2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  pantothenate kinase-associated neurodegeneration
      modeled by fbl1
      (Wu et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of lethal | pupal stage phenotype of fbl1

      (Wu et al., 2009)

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of short lived phenotype of fbl1

      (Wu et al., 2009)

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of abnormal locomotor behavior phenotype of fbl1

      (Wu et al., 2009)

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of sterile phenotype of fbl1

      (Wu et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of adult brain phenotype of fbl1

      (Wu et al., 2009)

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of retina phenotype of fbl1

      (Wu et al., 2009)

      Scer\GAL4Act.PU/Hsap\PANK2m.UAS is a suppressor of testis phenotype of fbl1

      (Wu et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PANK2m.Scer\UAS under the control of Scer\GAL4Act.PU in a fbl1 mutant background rescues the eclosion defects of fbl1 flies, and the lifespan of these animals recovers to almost normal levels. Locomotor defects and infertility are also rescued in these animals. Retinal and brain morphology is normal in these animals at 12 days and 30 days old.

      (Wu et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PANK2m.Scer\UAS
      Hsap\PANK2m.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)