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General Information
Symbol
Dmel\sotisik
Species
D. melanogaster
Name
FlyBase ID
FBal0246322
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Inferred boundaries of a 1939bp deletion resulting from the imprecise excision of P{XP}d01837 that removes the entire soti promoter and coding region.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A 1393 bp deletion comprising the entire promoter and coding regions of soti resulting from the imprecise excision of P{XP}d01837.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies homozygous for sotisik or in trans to Df(3R)Exel6267 are viable, female fertile, but male sterile.

Although sotisik mutant spermatids exhibit no gross defects during early and mid stages of spermatogenesis, severe defects are observed during spermatid individualization, and as a consequence, mature sperm are not accumulated in the seminal vesicle.

Whereas the cytoplasmic content of spermatids are normally removed from the post-individualized portions of the spermatids into the cystic bulge, in sotisik mutants, cystic bulges are remarkably flat due to a significant amount of cytoplasm which is left behind, in what is supposed to have been the post-individualized region of the spermatids. Notably, the advancement of the individualization complex (IC) toward the tail end of the spermatids is accompanied by a gradual increase in the severity of the observed individualization defects, such that eventually all the ICs arrest around the final quarter of the spermatid tails, exhibiting scattered investment cones and failure to generate mature waste bags.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

sotisik is a suppressor | partially of spermatid phenotype of Cul3mds5

Additional Comments
Genetic Interactions
Statement
Reference

Cul-3mds5 sotisik double mutants are infertile, but some limited translocation of individualization complexes in spermatids is observed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)