FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mmp2RNAi.UAS.cWa
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General Information
Symbol
Dmel\Mmp2RNAi.UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0246331
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
P{UAS-Mmp2.RNAi.W}
Key Links
Transgenic product class
RNAi_reagent
(Wang et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Wang et al., 2010)
Mutagen
in vitro construct
(Wang et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Mmp2.RNAi.W}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of Mmp2.

(Wang et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmp2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mmp2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4btl.PS (by inactivating Scer\GAL80ts.alphaTub84B through heat-shock), severely impairs air sac extension and results in a deformed structure. The characteristic elongated and pointed shape of the air sac is lost. Instead of a single well-defined tip, air sacs display multiple tips and occasionally a multi-lobed structure. Cell proliferation occurs normally.

      Randomly generated mutant cells expressing Mmp2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4btl.PS rarely populate the tip-cell territory in the air sac primordium.

      (Wang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mmp2RNAi.UAS.cWa
      Mmp2dsRNA.Scer\UAS.cWa
      Mmp2dsRNA.UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wang
      (Wang et al., 2010)
      Secondary FlyBase IDs
        References (2)