FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dhc64C902
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General Information
Symbol
Dmel\Dhc64C902
Species
D. melanogaster
Name
FlyBase ID
FBal0246424
Feature type
allele
Associated gene
Dmel\Dhc64C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Melkov et al., 2016)
Mutagen
ethyl methanesulfonate
(Li et al., 2008)
Progenitor genotype
Cytology
Description

A premature stop codon results in a truncated product without the DHC_N2 domain and with all four ATPase domains deleted.

(Li et al., 2008)

Amino acid replacement: W1173term.

(Li et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,820,045..4,820,045 [-]
Nucleotide change:

G4820045A

Amino acid change:

W1173term | Dhc64C-PA; W1173term | Dhc64C-PC; W1186term | Dhc64C-PD; W1173term | Dhc64C-PE; W1186term | Dhc64C-PF; W1173term | Dhc64C-PG; W1186term | Dhc64C-PH; W1186term | Dhc64C-PI

Reported amino acid change:

W1173term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dhc64C902 mutant follicle cells often become multiple-layered when located at the posterior end of the follicle after stage 6, which indicates a loss of A/B polarity.

      (Li et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dhc64C902
      (Melkov et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)