FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mob4EYΔL307
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General Information
Symbol
Dmel\Mob4EYΔL307
Species
D. melanogaster
Name
FlyBase ID
FBal0246735
Feature type
allele
Associated gene
Dmel\Mob4
Associated Insertion(s)
P{?EP}Mob4EYΔL307
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Schulte et al., 2010)
Progenitor genotype
P{EPgy2}Mob4EY23407
(Schulte et al., 2010)
Associated Insertion(s)
P{?EP}Mob4EYΔL307
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 116bp deletion starting at position -33. The deletion removes part of exon 1 and the downstream intron. A 17bp footprint of the insertion (CATGATGAAATAA) remains at the original insertion site.

(Schulte et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:6,696,317..6,696,432 [-]
Comment:

116 bp deletion resulting from the imprecise excision of P{EPgy2}Mob4EY23407. Reported as extending into the gene from the insertion site 33bp upstream of the Mob4 AUG.

(Schulte et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and Mob4EYΔL307/Mob4EYΔL3 adults have a significantly reduced lifespan compared to controls.

      Third instar mutant larvae have a "tail-flip" phenotype.

      Mob4EYΔL307 third larval instar neuromuscular junctions show relatively normal synaptic depression during 10 Hz stimulation in 2mM extracellular Ca[2+] but complete failure in EPSCs are seen after 4 seconds with a faster 50Hz stimulation train.

      (Schulte et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DMob4EYΔL307
      (Schulte et al., 2010)
      Mob4EYΔL307
      Name Synonyms
      Secondary FlyBase IDs
        References (1)