FlyBase Allele Report: Mmus\Ahr[UAS.cCa]

General Information

Symbol

Mmus\Ahr^UAS.cCa

Species

M. musculus

Name

Saccharomyces cerevisiae UAS construct a of Cespedes

FlyBase ID

FBal0247967

Feature type

allele

Associated gene

Mmus\Ahr

Associated Insertion(s)

Carried in Construct

P{UAS-Ahr.C}

Transgenic product class

wild_type

(Céspedes et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Céspedes et al., 2010)

Mutagen

in vitro construct

(Céspedes et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Ahr.C}

Cytology

Description

UASt regulatory sequences drive expression of Mmus\Ahr.

(Céspedes et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mmus\Ahr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | chemical conditional, with Scer\GAL4^GMR.PU

(Céspedes et al., 2010)

visible | chemical conditional, with Scer\GAL4^rn-GAL4

(Céspedes et al., 2010)

Phenotype Manifest In

eye | chemical conditional, with Scer\GAL4^GMR.PU

(Céspedes et al., 2010)

interommatidial bristle | chemical conditional, with Scer\GAL4^GMR.PU

(Céspedes et al., 2010)

leg | chemical conditional, with Scer\GAL4^rn-GAL4

(Céspedes et al., 2010)

Detailed Description

Statement

Reference

Expression of Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^rn-GAL4 (in the absence of dioxin) has no effect on leg morphogenesis. However, when these flies are exposed to dioxin, abnormal legs are produced.

Expression of Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU (in the absence of dioxin) has little effect on eye morphogenesis. However, when these flies are exposed to dioxin, eye defects are seen, including fused ommatidia and enlarged bristles.

(Céspedes et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Mmus\Ahr^UAS.cCa, Scer\GAL4^rn-GAL4, tgo^UAS.cWa has visible phenotype

(Céspedes et al., 2010)

Mmus\Ahr^UAS.cCa, Scer\GAL4^rn-GAL4, Vvvv\Arnt^UAS.cCa has visible phenotype

(Céspedes et al., 2010)

Mmus\Ahr^UAS.cCa, Scer\GAL4^GMR.PU, tgo^UAS.cWa has visible phenotype

(Céspedes et al., 2010)

Phenotype Manifest In

Other

Statement

Reference

Mmus\Ahr^UAS.cCa, Scer\GAL4^rn-GAL4, tgo^UAS.cWa has leg phenotype

(Céspedes et al., 2010)

Mmus\Ahr^UAS.cCa, Scer\GAL4^rn-GAL4, Vvvv\Arnt^UAS.cCa has leg phenotype

(Céspedes et al., 2010)

Mmus\Ahr^UAS.cCa, Scer\GAL4^GMR.PU, tgo^UAS.cWa has eye phenotype

(Céspedes et al., 2010)

Mmus\Ahr^UAS.cCa, Scer\GAL4^GMR.PU, tgo^UAS.cWa has interommatidial bristle phenotype

(Céspedes et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^rn-GAL4 can partially rescue the loss of tarsal segments seen in the legs of ss^sta/ss^abr flies. A greater degree of rescue is seen if the flies are exposed to dioxin.

Flies co-expressing tgo^Scer\UAS.cWa and Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^rn-GAL4 (in the absence of dioxin) show defects in the leg.

Flies co-expressing tgo^Scer\UAS.cWa and Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU (in the absence of dioxin) show eye defects, with fused ommatidia and enlarged bristles.

Flies co-expressing Vvvv\Arnt^Scer\UAS.cCa and Mmus\Ahr^Scer\UAS.cCa under the control of Scer\GAL4^rn-GAL4 (in the absence of dioxin) show defects in the leg.

(Céspedes et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mmus\Ahr^Scer\UAS.cCa

Mmus\Ahr^UAS.cCa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Cespedes

Secondary FlyBase IDs

References (1)

Report Sections

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