FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Capr2
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General Information
Symbol
Dmel\Capr2
Species
D. melanogaster
Name
FlyBase ID
FBal0248063
Feature type
allele
Associated gene
Dmel\Capr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Papoulas et al., 2010)
Mutagen
Delta2-3 transposase
(Papoulas et al., 2010)
Progenitor genotype
P{EPgy2}CaprEY06062
(Papoulas et al., 2010)
Cytology
Description

Deletion of 707 bp encompassing the first exon of Capr, including the ATG codon, generated by imprecise excision of P{EPgy2}CaprEY06062.

(Papoulas et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Capr2 mutant eyes, generated by eyFLP/FRT-mediated mitotic recombination in a Minute/+ background, are slightly reduced in size, with fewer ommatidia, than controls.

      (Baumgartner et al., 2013)

      Capr2/Df(3L)Cat flies show no obvious morphological defects.

      Embryos derived from Capr2/Df(3L)Cat females develop normally until the mid-blastula transition; cellularization, however, then occurs at a significantly reduced rate.

      (Papoulas et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Animals with eyes overexpressing ligdsRNA.Scer\UAS.II in a Capr2 background, generated using the eyFLP Actin-Flp out-Gal4 system, die as pharates, with increased and disturbed eyes structures.

      (Baumgartner et al., 2013)

      Capr2/Df(3L)Cat, Fmr13/+ flies are viable, but 50% of embryos laid by these females display a dramatic disruption in the timing of the mid-blastula transition: they initiate cleavage furrow formation normally, but enter mitosis 14 prematurely rather than undergoing a prolonged interphase. During the premature mitosis, the nascent cleavage furrows regress, only to reform during interphase of cycle 15, when the embryos attempt to complete cellularization. (No significant difference in nuclear cycle duration is seen until cycle 14, there are no signs of aberrant mitosis, and spindle morphology and nuclear spacing appears normal during mitosis 13 and 14.)

      Reduction of maternal CycB by one half (using the CycB2 allele) in the Capr2/Df(3L)Cat, Fmr13/+ background partially rescues the premature mitosis 14 phenotype seen in embryos of this genotype. (Reduction of the zygotic contribution of CycB has no effect.)

      (Papoulas et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Capr2
      (Baumgartner et al., 2013, Papoulas et al., 2010)
      capr2
      (Buddika et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)