FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\qless109
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General Information
Symbol
Dmel\qless109
Species
D. melanogaster
Name
FlyBase ID
FBal0248813
Feature type
allele
Associated gene
Dmel\qless
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Grant et al., 2010)
Progenitor genotype
Cytology
Description

Amino acid replacement: S215N.

(Grant et al., 2010)

Nucleotide substitution: G1354A.

(Grant et al., 2010)

Nucleotide/amino acid numbering based on qless-RA/-PA.

(Grant et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,241,663..31,241,663 [-]
Nucleotide change:

G31241663A

Reported nucleotide change:

G1354A

Amino acid change:

S215N | qless-PA; S215N | qless-PB

Reported amino acid change:

S215N

(Grant et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Post-embryonic generation of qless109 MARCM clones in the optic lobe, central brain or thoracic neuromeres results in dramatic reduction in neuroblast clonal growth by 96 hours after larval hatching. Whereas a single large mira[+] neuroblast is observed in each wild type clone, this cell type is missing in the majority of thoracic qless109 clones. There is also a large reduction in postmitotic progeny - qless109 clones in the central brain or thoracic neuromeres contain only ~20% or ~14%, respectively, of the wild type number of cells per clone.

      Dietary supplementation of with Coenzyme Q with side-chain length of 10, 9 or 4 isoprenoid units rescues the presence of a mira[+] neuroblast and the number of cells per clone in qless109 MARCM clones to near wild type levels in both the central brain and thoracic neuromeres.

      (Grant et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      qlessEP984

      (Grant et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      qless109
      (Grant et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)