FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\qless264
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General Information
Symbol
Dmel\qless264
Species
D. melanogaster
Name
FlyBase ID
FBal0248814
Feature type
allele
Associated gene
Dmel\qless
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Grant et al., 2010)
Progenitor genotype
Cytology
Description

DNA sequencing failed to identify any point mutations in the sequence coding for qless-PA.

(Grant et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Post-embryonic generation of qless109 MARCM clones in the optic lobe, central brain or thoracic neuromeres results in dramatic reduction in neuroblast clonal growth by 96 hours after larval hatching. Whereas a single large mira[+] neuroblast is observed in each wild type clone, this cell type is missing in the majority of thoracic qless109 clones. There is also a large reduction in postmitotic progeny - qless109 clones in the central brain or thoracic neuromeres contain only ~20% or ~14%, respectively, of the wild type number of cells per clone.

      Dietary supplementation of with Coenzyme Q with side-chain length of 10, 9 or 4 isoprenoid units rescues the presence of a mira[+] neuroblast and the number of cells per clone in qless264 MARCM clones to near wild type levels in both the central brain and thoracic neuromeres.

      Most neurons in qless264 MARCM clones at 96 hours after larval hatching are undergoing caspase-mediated apoptosis. qless264 cells also experience increased mitochondrial stress, as judged by Hsp60 upregulation.

      (Grant et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BacA\p35Scer\UAS.cHa within qless264 MARCM clones does not prevent mitochondrial stress, but does efficiently rescue the number of cells per qless264 clone.

      (Grant et al., 2010)
      Complementation and Rescue Data
      Fails to complement

      qlessEP984

      (Grant et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      qless264
      (Grant et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)