FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TTRUAS.cPa
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General Information
Symbol
Hsap\TTRUAS.cPa
Species
H. sapiens
Name
FlyBase ID
FBal0249060
Feature type
allele
Associated gene
Hsap\TTR
Associated Insertion(s)
Carried in Construct
P{UAS-TTR.P}
Key Links
Transgenic product class
cDNA
(Pokrzywa et al., 2007)
wild_type
(Pokrzywa et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Pokrzywa et al., 2007)
wild_type
(Pokrzywa et al., 2007)
Mutagen
in vitro construct
(Pokrzywa et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-TTR.P}
Cytology
Description

UASt regulatory sequences drive expression of wild-type Hsap\TTR cDNA sequences (including the native 20 amino acid long signal peptide).

(Pokrzywa et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\TTR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\TTRUAS.cPa under the control of Scer\GAL4GMR.PU leads to a progressive decrease in the climbing ability of adults.

      (Oliveira da Silva et al., 2020)

      Flies expressing Hsap\TTRScer\UAS.cPa under the control of Scer\GAL4GMR.PF exhibit Triton X-100 soluble Hsap\TTR protein both 1 day post-eclosion and 30 days post-eclosion.

      Increased overexpression of Hsap\TTRL55P.Scer\UAS under the control of two copies of Scer\GAL4GMR.PF has no effect on wing phenotype or lifespan.

      (Pokrzywa et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\TTRScer\UAS.cPa
      Hsap\TTRUAS.cPa
      TTRWT
      (Oliveira da Silva et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)