Galt^C2 mutants fed on 555mM glucose fly food with added doses of paraquat or dimetyl sulfoxide exhibit a dose-dependent sensitivity to these compounds, with increasing quantities resulting in increasing lethality.

Galt^C2 mutants fed on fly food containing 200mM galactose exhibit increased sensitivity and lower survival rates than wild-type flies fed on fly food containing 200mM galactose. Addition of 50, 100, and 200υM paraquat to the fly food decreased survival rates even further in these mutants, while wild-type flies are affected to a lesser degree. Addition of 67, 133, or 267υM dimetyl sulfoxide to fly food containing 200mM galactose results in a dose-dependent negative impact on Galt^C2 mutant larval survival. In the absence of galactose, the addition of dimetyl sulfoxide does not affect survival except when 267υM is added, which decreases survival to pupation and eclosion by just over 10%, compared to controls.

The addition of 20, 40, and 80υM vitamin C or 40, 120, and 360υM α-mangostin to galactose containing fly food results in a significant increase in the survival rates of Galt^C2 mutants.

GALT^C2 homozygotes demonstrate wild-type galactose-1-phosphate uridylyltransferase activity.