FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GaltΔ1V2
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General Information
Symbol
Dmel\GaltΔ1V2
Species
D. melanogaster
Name
FlyBase ID
FBal0249088
Feature type
allele
Associated gene
Dmel\Galt
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele

Mutagen
Nature of the Allele
Allele class

amorphic allele

(Kushner et al., 2010)
Mutagen
Delta2-3 transposase
(Kushner et al., 2010)
Progenitor genotype
P{SUPor-P}GaltKG00049
(Kushner et al., 2010)
Cytology
Description

Imprecise excision of P{SUPor-P}GALTKG00049 resulting in a 1647-bp deletion removing virtually the entire coding region of the GALT gene, with a small remnant of the P-element sequence left behind.

(Kushner et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:6,666,300..6,667,947 [-]
Comment:

1647 bp deletion resulting from the imprecise excision of P{SUPor-P}GaltKG00049, rmoves most of the Galt gene and leaves behind 13 bp of P-element sequence. Boundary sequences used to map deletion from Figure S1.

Inserted_sequence:

CATGATGAAATAA

(Kushner et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  galactosemia
      CEA
      (Kushner et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous GALTΔ1V2 flies in the progeny of homozygous GALTΔ1V2 mothers display galactose-dependent lethality: the mutants survive in the presence of dietary glucose, but they fail to survive if galactose is present in their food.

      Despite lifelong dietary restriction of galactose, GALTΔ1V2 homozygotes display impaired geotactic response.

      (Kushner et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      GALTΔ1V2/+ genetically complements +/cup01355.

      cupKG00049/+, +/GALTΔ1V2 females are viable and fertile.

      (Kushner et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\GALTScer\UAS.cKa driven by Scer\GAL4tub.PU rescues the abnormal geotactic response in GALTΔ1V2 homozygotes.

      (Kushner et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GALTΔ1V2
      GaltΔ1V2
      dGALTΔ1V2
      (Kushner et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)