FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gr59cUAS.cWa
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General Information
Symbol
Dmel\Gr59cUAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0249464
Feature type
allele
Associated gene
Dmel\Gr59c
Associated Insertion(s)
Carried in Construct
P{UAS-Gr59c.W}
Also Known As
UAS-Gr59c
Key Links
Transgenic product class
wild_type
(Weiss et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Weiss et al., 2011)
Mutagen
in vitro construct
(Weiss et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Gr59c.W}
Cytology
Description

UASt regulatory sequences drive expression of the Gr59c coding region.

(Weiss et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gr59c
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gr59cScer\UAS.cWa in the ab1C neruon, under the control of Scer\GAL4Gr21a.9.323 and Scer\GAL4Gr63a.PF confers responses to lobeline, denatonium, and escin, but not to caffeine, theophylline, or sucrose, which do not activate I-a bitter neurons.

      (Freeman et al., 2014)

      Expression of Gr59cScer\UAS.cWa under the control of Scer\GAL4Gr66a.1.8 does not increase the electrophysiological response of bitter-responsive classes of labellar sensilla to azadirachtin or caffeine, but decreases the response in many cases.

      (Weiss et al., 2011)

      Expression of Gr59cScer\UAS.cWa under the control of Scer\GAL4Gr66a.1.8 confers strong electrophysiological responses to each of the bitter compounds BER, DEN and LOB in the I[[8]], I[[9]] and I[[10]] labellar sensilla (these sensilla do not normally respond to these compounds).

      Expression of Gr59cScer\UAS.cWa under the control of Scer\GAL4Gr66a.1.8 increases the electrophysiological response of the I[[5]], S[[5]] and S[[6]] labellar sensilla to each of the bitter compounds BER, DEN and LOB compared to the response seen in wild-type controls.

      (Weiss et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Gr63a1 mutant background does not affect the Gr59cScer\UAS.cWa ab1C neuron response profile.

      (Freeman et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gr59cScer\UAS.cWa
      Gr59cUAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)