FB2026_02 , released June 18, 2026
Allele: Dmel\HP1bRNAi.Sym.UAS
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General Information
Symbol
Dmel\HP1bRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0256739
Feature type
allele
Associated gene
Dmel\HP1b
Associated Insertion(s)
Carried in Construct
P{Sym-UAS-HP1b}
Key Links
Transgenic product class
RNAi_reagent
(Zhang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Zhang et al., 2011)
Mutagen
in vitro construct
(Zhang et al., 2011)
Progenitor genotype
Carried in construct
P{Sym-UAS-HP1b}
Cytology
Description

A HP1b cDNA fragment (between 215 and 704bp in its open reading frame) is inserted into SympUAST.

(Zhang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
HP1b
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Knockdown of HP1b through expression of HP1bdsRNA.Sym.Scer\UAS under the control of Scer\GAL4Act.PU causes up to a 50% reduction in viability at the adult stage. The lethality of male flies is more severe than that of females.

      Knockdown of HP1b through expression of HP1bSym.Scer\UAS and HP1ba.Sym.Scer\UAS under the control of Scer\GAL4Act.PU causes up to a 50% reduction in viability at the adult stage. The lethality of male flies is more severe than that of females.

      (Zhang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HP1bRNAi.Sym.UAS
      HP1bSym.Scer\UAS
      HP1bdsRNA.Sym.Scer\UAS
      HP1bdsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0256740
      References (2)