FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Desat1EpB3
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General Information
Symbol
Dmel\Desat1EpB3
Species
D. melanogaster
Name
FlyBase ID
FBal0256866
Feature type
allele
Associated gene
Dmel\Desat1
Associated Insertion(s)
P{EP}Desat1EpB3
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}Desat1EpB3
    Cytology
    Description

    Insertion between the RE and RB alternative 5' UTR exons. The element is inserted such that overexpression from the element using a Scer\GAL4 driver will result in transcription in the same orientation as the orientation of desat1 transcription.

    (Houot et al., 2010)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous males show an increase in the total amount of cuticular hydrocarbons compared to control males. They show a significant increase in the relative proportion of linear cuticular hydrocarbons compared to control males.

        Males expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-1 in a desat11573-1/+ background show an increase in the total amount of cuticular hydrocarbons compared to control males. The mutant males show a significant decrease in the relative proportion of desaturated cuticular hydrocarbons and a significant increase in the relative proportions of both linear and methyl branched cuticular hydrocarbons compared to control males.

        Males expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-C'1 in a desat11573-C'1/+ background show an increase in the total amount of cuticular hydrocarbons compared to control males. The mutant males show a significant decrease in the relative proportions of both desaturated and methyl branched cuticular hydrocarbons and a significant increase in the relative proportion of linear cuticular hydrocarbons compared to control males.

        Homozygous females show an increase in the total amount of cuticular hydrocarbons compared to control females. The relative proportions of linear, desaturated and methyl branched cuticular hydrocarbons is the same in homozygous and control females.

        Females expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-1 in a desat11573-1/+ background show an increase in the total amount of cuticular hydrocarbons compared to control females. The mutant females show a significant decrease in the relative proportions of desaturated cuticular hydrocarbons compared to control females.

        Females expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-C'1 in a desat11573-C'1/+ background show an increase in the total amount of cuticular hydrocarbons compared to control females. The mutant females show a significant decrease in the relative proportions of both desaturated and methyl branched cuticular hydrocarbons compared to control females.

        Males expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-1 in a desat11573-1/+ background show a normally high ability to discriminate between male and female control flies in a courtship assay, having a significantly higher courtship index towards females than towards males.

        Males expressing desat1EpB3 under the control of Scer\GAL4desat1-1573-C'1 in a desat11573-C'1/+ background do not discriminate between male and female control flies in a courtship assay.

        Homozygous males show a normally high ability to discriminate between male and female control flies in a courtship assay, having a significantly higher courtship index towards females than towards males.

        (Houot et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Desat1EpB3
        EpB3
        (Houot et al., 2010)
        desat1EpB3
        Name Synonyms
        Secondary FlyBase IDs
          References (1)