FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ltlUAS.cSa
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General Information
Symbol
Dmel\ltlUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Szuperak
FlyBase ID
FBal0256901
Feature type
allele
Associated gene
Dmel\ltl
Associated Insertion(s)
Carried in Construct
P{UAS-ltl.S}
Key Links
Transgenic product class
wild_type
(Szuperák et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Szuperák et al., 2011)
Mutagen
in vitro construct
(Szuperák et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-ltl.S}
Cytology
Description

UAS regulatory sequences drive expression of ltl.

(Szuperák et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ltl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ltlScer\UAS.cSa under the control of Scer\GAL4A9 results in an approximately 20% reduction in wing size compared with controls. The posterior crossvein is completely eliminated and the anterior crossvein is eliminated or disrupted.

      Expression of ltlScer\UAS.cSa under the control of Scer\GAL4en-e16E causes a reduction in wing size and loss of the posterior crossvein.

      (Szuperák et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ltlUAS.cSa is a suppressor of visible phenotype of cv-21

      (Szuperák et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ltlUAS.cSa is a suppressor of posterior crossvein phenotype of cv-21

      (Szuperák et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Two copies of P{UAS-ltl.S}5 (which allow leaky expression of ltlScer\UAS.cSa in the absence of a Scer\GAL4 driver) fully restore the posterior crossvein in 45% of wings of cv-21/cv-21 animals.

      Co-expression of ltlScer\UAS.cSa and cv-2Scer\UAS.cBa under the control of Scer\GAL4en-e16E results in additive effects on wing size reduction and synergistic effects on wing patterning, including deletions of vein L4 in the proximity of the presumptive posterior crossvein.

      (Szuperák et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ltlScer\UAS.cSa
      ltlUAS.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Szuperak
      Secondary FlyBase IDs
        References (1)