FB2026_02 , released June 18, 2026
Allele: Dmel\Desat1119A
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General Information
Symbol
Dmel\Desat1119A
Species
D. melanogaster
Name
FlyBase ID
FBal0256993
Feature type
allele
Associated gene
Dmel\Desat1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Köhler et al., 2009)
Mutagen
Delta2-3 transposase
(Köhler et al., 2009)
Progenitor genotype
P{EPgy2}Desat1EY07679
(Köhler et al., 2009)
Cytology
Description

Imprecise excision of P{EPgy2}desat1EY07679 resulting in the deletion of the first coding exon of desat1.

(Köhler et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygosity for allele desat1119A and the heteroallelic combination desat111A/desat1119A result in larval lethality with larvae dying during the second larval instar stage (L2), where they remain for up to three days without being able to moult into larval stage three (L3). Very few escapers are able to develop until L3. The mutant larvae are reduced in size and fail to develop beyond L3. The mutant L2 larvae stop feeding and leave the food source.

      Clones of homozygous desat1119A mutant fat body cells show abnormal autophagic response to starvation.

      (Köhler et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Desat1119A
      Desat119A
      (Köhler et al., 2009)
      desat1119
      (Huang et al., 2016)
      desat1119A
      Name Synonyms
      Secondary FlyBase IDs
        References (2)