FlyBase Allele Report: Dmel\CtsL1[HMS00725]

General Information

Symbol

Dmel\CtsL1^HMS00725

Species

D. melanogaster

Name

FlyBase ID

FBal0257408

Feature type

allele

Associated gene

Dmel\CtsL1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00725}

Also Known As

HMS00725, CP1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00725}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00725

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Lee et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of alcohol use disorder

is ameliorated by Dpse\GA25021^UAS.cLa

(Lee et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage | oogenesis stage S14, with Scer\GAL4^GR1

(Mondragon et al., 2019)

nurse cell | oogenesis stage S13, with Scer\GAL4^GR1

(Mondragon et al., 2019)

nurse cell | oogenesis stage S14 | increased number, with Scer\GAL4^GR1

(Mondragon et al., 2019)

Detailed Description

Statement

Reference

Expression of Cp1^HMS00725 under the control of Scer\GAL4^GR1 leads to a significant reduction in cell death (TUNEL) in nurse cells at oogenesis stage 13, persisting nurse cells (myr-GFP) and defects in formation of dorsal appendages at oogenesis stage 14 while it does not lead to any nurse cell acidification defects (LysoTracker) at oogenesis stage 13 in egg chambers when compared to controls.

(Mondragon et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CtsL1^HMS00725, Scer\GAL4^repo has chemical sensitive | adult stage phenotype, suppressible by Dpse\GA25021^UAS.cLa, Scer\GAL4^repo

(Lee et al., 2019)

Phenotype Manifest In