FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\domLL05537
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General Information
Symbol
Dmel\domLL05537
Species
D. melanogaster
Name
FlyBase ID
FBal0258203
Feature type
allele
Associated gene
Dmel\dom
Associated Insertion(s)
PBac{SAstopDsRed}domLL05537
Carried in Construct
Also Known As
LL05537
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Tea and Luo, 2011)
Progenitor genotype
Associated Insertion(s)
PBac{SAstopDsRed}domLL05537
Cytology
Description

Insertion of PBac{SAstopDsRed} in an intron just upstream of the translation start of dom.

(Tea and Luo, 2011)
Allele components
Component
Use(s)
Inserted element
PBac{SAstopDsRed}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In domLL05537 mutants, PBac{GH146-GAL4.B}-marked DL1 olfactory projection neurons mistarget some of their dendrites to the dorsolateral glomerulus DA41 in the anterior of the antennal lobe instead of the DL1 glomerulus in the posterior of the antennal lobe as in wild type. However, arborization of mutant axons is not obviously altered.

      PBac{GH146-GAL4.B}-marked anterodorsal and lateral projection neuron neuroblast clones in domLL05537 mutants have a very mild reduction in cell number and their dendrites do no t traget to the full set of proper glomeruli.

      PBac{GH146-GAL4.B}-marked ventral projection neuron neuroblast clones in domLL05537 mutants exhibit incomplete targeting throughout the antennal lobe.

      (Tea and Luo, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      domLL05537 has abnormal neuroanatomy | recessive phenotype, non-enhanceable by Bap55UAS.cTa/Scer\GAL4GH146.PB

      (Tea and Luo, 2011)
      NOT suppressed by
      Statement
      Reference

      domLL05537 has abnormal neuroanatomy | recessive phenotype, non-suppressible by Bap55UAS.cTa/Scer\GAL4GH146.PB

      (Tea and Luo, 2011)
      Phenotype Manifest In
      NOT Enhanced by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Bap55Scer\UAS.cTa using Scer\GAL4GH146.PB does not significantly alter the dendrite mistargeting phenotype of domLL05537 mutants.

      (Tea and Luo, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the PBac{SAstopDsRed} element reverts the domLL05537 dendrite mistargeting phenotype.

      (Tea and Luo, 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      LL05537
      (Tea and Luo, 2011)
      dom-
      (Tea and Luo, 2011)
      domLL05537
      (Flegel et al., 2016, Kirilly et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)