FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Mmus\Opn4ninaE.PS
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General Information
Symbol
Mmus\Opn4ninaE.PS
Species
M. musculus
Name
neither inactivation nor afterpotential E promoter construct of Shen
FlyBase ID
FBal0258392
Feature type
allele
Associated gene
Mmus\Opn4
Associated Insertion(s)
Carried in Construct
P{ninaE-Opn4.S}
Transgenic product class
wild_type
(Shen et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Shen et al., 2011)
Mutagen
in vitro construct
(Shen et al., 2011)
Progenitor genotype
Carried in construct
P{ninaE-Opn4.S}
Cytology
Description

ninaE promoter sequences drive expression of Mmus\Opn4.

(Shen et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
Mmus\Opn4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mmus\Opn4ninaE.PS is a suppressor of abnormal size | adult stage phenotype of ninaE17

      (Yasin et al., 2017)

      Mmus\Opn4ninaE.PS is a suppressor of abnormal thermotaxis | larval stage phenotype of ninaE17

      (Shen et al., 2011)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Mmus\Opn4ninaE.PS partially suppresses the reduced rhabdomere size observed in ninaE17 mutants, although the rhabdomeres also show deformed structure, and abnormal actin localization, as compared to wild type. Flies expressing Mmus\Opn4ninaE.PS in a ninaE17 background also exhibit defects in photoreceptor light induced currents, with reduced sensitivity to light stimuli, and abnormal continuous production of quantum bump-like unitary currents, as compared to wild type.

      (Yasin et al., 2017)

      Expression of Mmus\Opn4ninaE.PS rescues the ability of ninaE17 larvae to strongly discriminate between 18[o]C and 24[o]C in a binary choice thermotaxis assay.

      (Shen et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Opn4ninaE.PS
      Name Synonyms
      neither inactivation nor afterpotential E promoter construct of Shen
      Secondary FlyBase IDs
        References (2)