FlyBase Allele Report: Dmel\REG[KK102083]

General Information

Symbol

Dmel\REG^KK102083

Species

D. melanogaster

Name

FlyBase ID

FBal0259103

Feature type

allele

Associated gene

Dmel\REG

Associated Insertion(s)

Carried in Construct

P{KK102083}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102083}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102083

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^ap.PU

(Li et al., 2015)

visible | adult stage, with Scer\GAL4^ap.PU

(Li et al., 2015)

visible | adult stage, with Scer\GAL4^Bx-MS1096

(Li et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PU

(Li et al., 2015)

visible | adult stage, with Scer\GAL4^hh.PU

(Li et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Li et al., 2015)

wing blade, with Scer\GAL4^ap.PU

(Li et al., 2015)

wing blade, with Scer\GAL4^Bx-MS1096

(Li et al., 2015)

wing blade, with Scer\GAL4^hh.PU

(Li et al., 2015)

wing disc | third instar larval stage, with Scer\GAL4^ap.PU

(Li et al., 2015)

Detailed Description

Statement

Reference

Expression of REG^KK102083 RNAi under the control of Scer\GAL4^ap.PU results in a significant increase in the level of cell death (detected by Casp3 antibody staining) in third instar larval wing discs compared to controls.

Expression of REG^KK102083 under the control of any of the following: Scer\GAL4^Bx-MS1096, Scer\GAL4^ap.PU and Scer\GAL4^hh.PU results in small and severely misshapen adult wings (and with a significant portion of the posterior part of the wing missing in case of the Scer\GAL4^hh.PU-driven expression). Expression under the Scer\GAL4^ey.PU driver leads to much reduced adult eye size.

(Li et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

REG^KK102083, Scer\GAL4^ap.PU has increased cell death | third instar larval stage phenotype, suppressible | partially by Myc^JF01761, Scer\GAL4^ap.PU

(Li et al., 2015)

REG^KK102083, Scer\GAL4^ap.PU has increased cell death | third instar larval stage phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^ap.PU

(Li et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

REG^KK102083, Scer\GAL4^ap.PU has wing disc | third instar larval stage phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^ap.PU

(Li et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The increased level of cell death (detected by Casp3 antibody staining) observed in wing discs of third instar larvae expressing REG^KK102083 RNAi under the control of Scer\GAL4^ap.PU is partially or fully suppressed by co-expression of Myc^JF01761 RNAi or Diap1^Scer\UAS.cHa, respectively.

(Li et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110156

P{KK102083}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

REG^KK102083

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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