FlyBase Allele Report: Dmel\Pka-C1[GL00038]

General Information

Symbol

Dmel\Pka-C1^GL00038

Species

D. melanogaster

Name

FlyBase ID

FBal0262529

Feature type

allele

Associated gene

Dmel\Pka-C1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00038}

Also Known As

GL00038, UAS-pka-c1-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00038}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00038

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Scer\GAL4^tim.PE

(Zhang and Emery, 2013)

abnormal wound healing | third instar larval stage, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

decreased cell growth rate | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

axon | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

motor neuron | third instar larval stage | conditional, with Scer\GAL4^tey-5053A

(Hao et al., 2016)

Detailed Description

Statement

Reference

Expression of Pka-C1^GL00038 under the control of Scer\GAL4^tey-5053A (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to suppressed growth response of motoneuron axons after nerve crush injury, as compared to wild type.

(Hao et al., 2016)

Females heterozygous for Pka-C1^GL00038 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Pka-C1^GL00038 males results in: 3% hatching; egg/embryonic phenotype: all eggs white and empty; tiny eggs; maternal effect.

(Sopko et al., 2014)

Flies expressing Pka-C1^GL00038 under the control of Scer\GAL4^tim.PE (in the presence of Dcr-2^Scer\UAS.cDa to increase RNAi efficiency) are completely arrhythmic for locomotor activity under constant darkness conditions.

(Zhang and Emery, 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35169

y¹ sc^* v¹ sev²¹; P{TRiP.GL00038}attP2

NIG-Fly

GL00038

y¹ sc^* v¹ sev²¹; P{TRiP.GL00038}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pka-C1^GL00038

Pka-C1^RNAi

(Zhang and Emery, 2013)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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