FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PrpsGL00463
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General Information
Symbol
Dmel\PrpsGL00463
Species
D. melanogaster
Name
FlyBase ID
FBal0262928
Feature type
allele
Associated gene
Dmel\Prps
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00463}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00463}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00463
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing CG6767GL00463 under the control of Scer\GAL4elav.PLu, Scer\GAL4H24, Scer\GAL4GH298 or Scer\GAL4NP2426 display a significantly increased aversion to 2,3-butanedione in an olfactometer assay, while expression under the control of Scer\GAL4Mef2.247 results in a significant reduction in attraction compared to controls. Additionally, a significant reduction in attraction is observed in a T-maze assay when expression is under the control of Scer\GAL4elav.PLu, Scer\GAL4H24 or Scer\GAL4Mef2.247 and increased aversion is maintained under various odorant concentrations when expression is under the control of Scer\GAL4H24.

      Adult flies expressing CG6767GL00463 under the control of Scer\GAL4H24 display a significantly increased aversion to D-Carvone, a significant reduction in attraction to 2-Heptanone and a similar preference to Ethyl Acetate or Methly Hexanoate compared to controls.

      Adult flies expressing CG6767GL00463 under the control of Scer\GAL4GH146, Scer\GAL4Orco.2.642.Hsim\VP22, Scer\GAL4Tab2-201Y, Scer\GAL4c305a, Scer\GAL4c739 or Scer\GAL4kra-krasavietz display a similar preference to 2,3-butanedione as controls.

      (Brown et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG6767GL00463
      PrpsGL00463
      Name Synonyms
      Secondary FlyBase IDs
        References (5)