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General Information
Symbol
Dmel\Epg5GL00468
Species
D. melanogaster
Name
FlyBase ID
FBal0262933
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Epg5GL00468 under the control of Scer\GAL4cg.PU leads to a failure of the late phases of autophagic digestion in the larval fat body upon starvation for 6 hours, indicated by correct formation of, but subsequent digestion of autophagosomes, and abnormal accumulation of large vacuoles in the fat body, but no obvious change in the shape of other cellular structures, as compared with controls.

Expression of Epg5GL00468 under the control of Scer\GAL4GMR.PU (using a temperature sensitive GAL80 allele to restrict expression to the adult stage) results in progressive loss of photoreceptor neurons in the adult retina.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG14299GL00468
Epg5GL00468
Name Synonyms
Secondary FlyBase IDs
    References (2)