FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dcr-2R269W
Open Close
General Information
Symbol
Dmel\Dcr-2R269W
Species
D. melanogaster
Name
FlyBase ID
FBal0264052
Feature type
allele
Associated gene
Dmel\Dcr-2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lim et al., 2008)
Mutagen
ethyl methanesulfonate
(Lim et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: R269W.

(Lim et al., 2008)

Missense mutation in the helicase domain.

(Lim et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,579,946..17,579,946 [-]
Nucleotide change:

C17579946T

Amino acid change:

R269W | Dcr-2-PA; R269W | Dcr-2-PB

Reported amino acid change:

R269W

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lim et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Dcr-2R269W is a suppressor of abnormal eye color phenotype of wRNAi.GMR

      (Lim et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wIR.GMR eyes that are also homozygous for Dcr-2R269W show stronger eye pigmentation compared to wIR.GMR eyes.

      (Lim et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dcr-2R269W
      dcr-2R269W
      (Lim et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)