FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kal1N236K.UAS
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General Information
Symbol
Dmel\Kal1N236K.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264059
Feature type
allele
Associated gene
Dmel\Kal1
Associated Insertion(s)
Carried in Construct
P{UAS-Kal1.N236K}
Key Links
Transgenic product class
missense_variant
(Andrenacci et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Andrenacci et al., 2006)
Mutagen
in vitro construct
(Andrenacci et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Kal1.N236K}
Cytology
Description

UASt drives expression of the Kal1 cDNA bearing a N236K substitution in the first FnIII domain.

(Andrenacci et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Kal1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Depending on the insertion used, 28-86% of Scer\GAL4179Y, Kal1N236K.Scer\UAS larvae fail to hatch from the egg,

      Expression of Kal1N236K.Scer\UAS with Scer\GAL4179Y results in profound head alterations, including abnormal median tooth development as well as mouth hook defects and a skeleton with a less sclerotized structure. Head involution defects are also evident, and a significant number of embryos show incomplete germband retraction.

      Expression of Kal1N236K.Scer\UAS with Scer\GAL4Bx-MS1096 induced lethality and wing defects similar to expression of Kal1Scer\UAS.cAa.

      (Andrenacci et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kal1N236K.Scer\UAS
      Kal1N236K.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)