FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kal1C85S.UAS
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General Information
Symbol
Dmel\Kal1C85S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264062
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt drives expression of the Kal1 cDNA bearing a C85S substitution within the N-terminal cysteine-rich domain.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One out of five different Kal1C85S.Scer\UAS insertions shows reduced viability and delay of hatching when expressed with Scer\GAL4179Y. The head skeleton shows a thin structure, while the mouth hooks base show only a reduction in the dorsal process. There is a small increase in the lethality rate if the Kal1C85S.Scer\UAS copy number is increased. (Expression of the other insertions does not produce a phenotype.)

Expression of Kal1C85S.Scer\UAS using Scer\GAL4Bx-MS1096 produces mild wing phenotypes, though a broad splitting of the L4 vein is often seen and wings are reduced in the proximal-distal axis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Kal1C85S.Scer\UAS
Kal1C85S.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)