FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kal1R159T.R161L.UAS
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General Information
Symbol
Dmel\Kal1R159T.R161L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264063
Feature type
allele
Associated gene
Dmel\Kal1
Associated Insertion(s)
Carried in Construct
P{UAS-Kal1.R159T.R161L}
Key Links
Transgenic product class
missense_variant
(Andrenacci et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Andrenacci et al., 2006)
Mutagen
in vitro construct
(Andrenacci et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Kal1.R159T.R161L}
Cytology
Description

UASt drives expression of the Kal1 cDNA bearing R159T and R161L substitutions within the predicted heparan-sulfate binding site.

(Andrenacci et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Kal1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Kal1R159T.R161L.Scer\UAS using Scer\GAL4179Y induces lethality, delay in hatching, and defects in the head skeleton similar to expression of Kal1Scer\UAS.cAa.

      At 18[o]C, expression of Kal1R159T.R161L.Scer\UAS using Scer\GAL4Bx-MS1096 induces a small reduction of the proximal-distal axis of the wing with no other visible defects. At 25[o]C, there is a stronger reduction of the proximal-distal axis of the wing and frequently a splitting of vein L4. Reduction of the L2-L3 intervein region and notching of the L3-L5 wing margin is occasionally seen.

      (Andrenacci et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kal1R159T.R161L.Scer\UAS
      Kal1R159T.R161L.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)