FlyBase Allele Report: Dmel\Sdc[RESC.UAS]

General Information

Symbol

Dmel\Sdc^RESC.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0264315

Feature type

allele

Associated gene

Dmel\Sdc

Associated Insertion(s)

Carried in Construct

P{UAS-Sdc.RESC}

Also Known As

sdc^RESC

Key Links

Transgenic product class

wild_type

(Schulz et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Schulz et al., 2009)

Mutagen

in vitro construct

(Schulz et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Sdc.RESC}

Cytology

Description

UAS regulatory sequences drive expression of a version of Sdc containing 72 silent mutations in the 375bp region that is targeted by P{UAS-Sdc.RNAi.S}, to produce an RNAi resistant form (RNAi Escape Strategy Construct (RESC) method).

(Schulz et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sdc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Sdc^RESC.UAS/Scer\GAL4^btl.PS is a non-enhancer of adult dorsal tracheal branch | third instar larval stage phenotype of Scer\GAL4^btl.PS, comm^UAS.Tag:MYC

(Schulz et al., 2011)

Suppressor of

Statement

Reference

Sdc^RESC.UAS/Scer\GAL4^btl.PS is a suppressor | partially of adult dorsal tracheal branch | third instar larval stage phenotype of Scer\GAL4^btl.PS, robo2^UAS.GFP

(Schulz et al., 2011)

Sdc^RESC.UAS/Scer\GAL4^btl.PS is a suppressor | partially of adult dorsal tracheal branch | third instar larval stage phenotype of Scer\GAL4^btl.PS, robo1^UAS.GFP

(Schulz et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sdc^{RESC.Scer\UAS} suppresses the dorsal branch fusion phenotype seen when lea^{Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^btl.PS.

Expression of Sdc^{RESC.Scer\UAS} suppresses the dorsal branch fusion phenotype seen when robo^{Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^btl.PS.

Expression of Sdc^{RESC.Scer\UAS} does not enhance the dorsal branch fusion phenotype seen when comm^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^btl.PS in the tracheal system of third instar larvae.

(Schulz et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Sdc^RESC.UAS/Scer\GAL4^btl.PS rescues Sdc^RNAi.UAS.cSa

(Schulz et al., 2011)

Sdc^RESC.UAS/Scer\GAL4^esg-p127 rescues Sdc^RNAi.UAS.cSa

(Schulz et al., 2011)

Sdc^RESC.UAS/Scer\GAL4^btl.PS rescues Sdc^RNAi.UAS.cSa

(Schulz et al., 2009)

Partially rescues

Sdc^RESC.UAS/Scer\GAL4^btl.PS partially rescues Sdc²⁶³⁹

(Schulz et al., 2011)

Comments

Expression of Sdc^{RESC.Scer\UAS} rescues the dorsal branch fusion phenotype seen when Sdc^{dsRNA.Scer\UAS.cSa} is expressed under the control of Scer\GAL4^btl.PS.

Expression of Sdc^{RESC.Scer\UAS} rescues the dorsal branch fusion phenotype seen when Sdc^{dsRNA.Scer\UAS.cSa} is expressed under the control of Scer\GAL4^esg-p127.

Expression of Sdc^{RESC.Scer\UAS} under the control of Scer\GAL4^btl.PS rescues the loss of dorsal branch fusion seen in Sdc²⁶³⁹ mutants, but fails to rescue the semi-lethality.

(Schulz et al., 2011)

Expression of Sdc^{RESC.Scer\UAS} rescues the tracheal dorsal branch defects seen when Sdc^{dsRNA.Scer\UAS.cSa} is expressed under the control of Scer\GAL4^btl.PS.

(Schulz et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sdc^{RESC.Scer\UAS}

Sdc^RESC.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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