FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vha100-1R755A.UAS
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General Information
Symbol
Dmel\Vha100-1R755A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264500
Feature type
allele
Associated gene
Dmel\Vha100-1
Associated Insertion(s)
Carried in Construct
P{UAS-Vha100-1.R755A}
Also Known As
UAS-v100R755A
Key Links
Transgenic product class
missense_variant
(Williamson et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Williamson et al., 2010)
Mutagen
in vitro construct
(Williamson et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Vha100-1.R755A}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Vha100-1 that contains the amino acid replacement R755A.

(Williamson et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Vha100-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4drm.7.1-mediated expression of Vha100-1R755A.Scer\UAS results in tracheal stalk cells aberrantly forming two or more connections to a neighbouring terminal cell and long, branched autocellular, seamed tubes extending well beyond the terminal cell nucleus.

      (Francis and Ghabrial, 2015)

      The electroretinogram has an on transient, but shows a decrease in depolarisation compared to wild type in photoreceptors in which Vha100-1R755A.Scer\UAS is expressed under the control of Scer\GAL4unspecified.

      Animals expressing Vha100-1R755A.Scer\UAS under the control of Scer\GAL4unspecified in a Vha100-14 background show loss of photoreceptors and have a reduced eye phenotype.

      (Williamson et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4unspecified/Vha100-1R755A.UAS partially rescues Vha100-14

      (Williamson et al., 2010)
      Comments

      The on transient of the electroretinogram is significantly rescued in Vha100-14 mutant photoreceptors in which Vha100-1R755A.Scer\UAS is expressed under the control of Scer\GAL4unspecified, although this is accompanied by a pronounced decrease in electroretinogram depolarisation.

      The acidification defects seen in Vha100-14 mutant photoreceptors after neuronal differentiation are not rescued by expression of Vha100-1R755A.Scer\UAS in the photoreceptors under the control of Scer\GAL4unspecified.

      (Williamson et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vha100-1R755A.Scer\UAS
      Vha100-1R755A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)