FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Utx2
Open Close
General Information
Symbol
Dmel\Utx2
Species
D. melanogaster
Name
FlyBase ID
FBal0264574
Feature type
allele
Associated gene
Dmel\Utx
Associated Insertion(s)
Carried in Construct
Also Known As
dUTX2
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Herz et al., 2010)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: C1071Y.

    (Herz et al., 2010)

    Missense mutation in the C terminus.

    (Herz et al., 2010)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:10,273,000..10,273,000 [-]
    Nucleotide change:

    G10273000A

    Amino acid change:

    C1071Y | Utx-PA; C874Y | Utx-PB; C874Y | Utx-PC; C1065Y | Utx-PD; C869Y | Utx-PE

    Reported amino acid change:

    C1071Y

    Comment:

    The position of the mutation was reported relative to isoform Utx-PA. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Herz et al., 2010)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Huntington's disease
        modeled by Hsap\HTTQ93.ex1.UAS
        (Song et al., 2018)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The overall size of Utx2 mosaic eyes is normal; however, Utx2 mutant tissue represents a larger fraction of the eye.

        (Herz et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Utx2/Utx[+] is a suppressor of wing margin phenotype of Ser1

        (Herz et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The wing notching phenotype of Ser1 or Df(1)N-8 heterozygotes is dominantly suppressed by Utx2.

        (Herz et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Utx2
        (Song et al., 2018)
        dUTX2
        (Denton et al., 2013, Herz et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)