FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SNF4AγRNAi.UAS
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General Information
Symbol
Dmel\SNF4AγRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0264829
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of SNF4Aγ coding sequences arranged in an inverted repeat to generate dsRNA.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4109(2)80 results in aberrant morphology in class IV multi-dendritic neurons.

Expression SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4Ubi significantly reduces adult lifespan.

Heat-shock induced expression of SNF4AγdsRNA.Scer\UAS (under the control of Scer\GAL4hs.PB) in adult stages produces a significant reduction in starvation survival and starvation sensitivity is indistinguishable in these animals from controls. These animals also exhibit a significant reduction in lifespan under nutrient-rich conditions.

Ubiquitous expression of SNF4AγdsRNA.Scer\UAS (under the control of Scer\GAL4Ubi) results in significantly lower amounts of locomotion during normal, unstressed conditions as compared to controls. However, these flies show an instant increase in activity levels when faced with starvation, as oppose to a steady increase as found in wild-type controls, indicating lower locomotion levels in a fed-state, and elevated locomotion levels in a starvation state.

Total daily food intake is significantly increased in animals expressing SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4Ubi, independent of nutritional value. Specifically, in both males and females, total dietary intake is nearly twice that of animals with wild-type SNF1A function.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
SNF4AγRNAi.UAS
SNF4AγdsRNA.Scer\UAS
SNF4AγdsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)