Expression of SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4109(2)80 results in aberrant morphology in class IV multi-dendritic neurons.
Expression SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4Ubi significantly reduces adult lifespan.
Heat-shock induced expression of SNF4AγdsRNA.Scer\UAS (under the control of Scer\GAL4hs.PB) in adult stages produces a significant reduction in starvation survival and starvation sensitivity is indistinguishable in these animals from controls. These animals also exhibit a significant reduction in lifespan under nutrient-rich conditions.
Ubiquitous expression of SNF4AγdsRNA.Scer\UAS (under the control of Scer\GAL4Ubi) results in significantly lower amounts of locomotion during normal, unstressed conditions as compared to controls. However, these flies show an instant increase in activity levels when faced with starvation, as oppose to a steady increase as found in wild-type controls, indicating lower locomotion levels in a fed-state, and elevated locomotion levels in a starvation state.
Total daily food intake is significantly increased in animals expressing SNF4AγdsRNA.Scer\UAS under the control of Scer\GAL4Ubi, independent of nutritional value. Specifically, in both males and females, total dietary intake is nearly twice that of animals with wild-type SNF1A function.