FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Upf113D
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General Information
Symbol
Dmel\Upf113D
Species
D. melanogaster
Name
FlyBase ID
FBal0264863
Feature type
allele
Associated gene
Dmel\Upf1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Metzstein and Krasnow, 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: C186Y.

(Metzstein and Krasnow, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,904,293..11,904,293 [-]
Nucleotide change:

G11904293A

Amino acid change:

C186Y | Upf1-PA; C186Y | Upf1-PB

Reported amino acid change:

C186Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Metzstein and Krasnow, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      83.4% of eggs derived from homozygous female germlines show a fused dorsal appendage phenotype.

      Homozygous follicle cell clones are smaller than wild-type clones both in early, proliferating egg chambers and in late, endocycling egg chambers.

      (Avery et al., 2011)

      While homozygous mutant Upf113D clones are readily obtained from the larval tracheal system, clones are not recovered in the adult system. Large clones are also not recovered from the adult epidermis or eyes, Although small peripheral eye clones are occasionally observed.

      (Metzstein and Krasnow, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Upf126A

      (Metzstein and Krasnow, 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Upf113D
      (Metzstein and Krasnow, 2006)
      upf113D
      (Avery et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)