FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tim17bRNAi.UAS
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General Information
Symbol
Dmel\Tim17bRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0265603
Feature type
allele
Associated gene
Dmel\Tim17b
Associated Insertion(s)
Carried in Construct
P{UAS-Tim17b.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Garabedian et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Garabedian et al., 2011)
Mutagen
in vitro construct
(Garabedian et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Tim17b.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 693bp Tim17b fragment from the CK01513 cDNA clone. A 720bp fragment of DsRed is inserted between the two copies of the repeat as a spacer.

(Garabedian et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tim17b
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ubiquitous expression of Tim17bdsRNA.Scer\UAS under the control of Scer\GAL4unspecified results in most animals arresting development and dying at an early embryonic stage. The mitochondria of the midgut of escaper second instar larvae usually appear abnormal; an abnormal structure surrounded by a double membrane with residual cristae is often seen. The brains of escaper first instar larvae show an increase in apoptosis compared to wild type.

      (Garabedian et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Tim17bRNAi.UAS
      Tim17bdsRNA.Scer\UAS
      Tim17bdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)