FB2026_02 , released June 18, 2026
Allele: Dmel\RNaseMRP:RNAEY08633
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General Information
Symbol
Dmel\RNaseMRP:RNAEY08633
Species
D. melanogaster
Name
FlyBase ID
FBal0265653
Feature type
allele
Associated gene
Dmel\RNaseMRP:RNA
Associated Insertion(s)
P{EPgy2}CG10365EY08633
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}CG10365EY08633
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        RNaseMRP:RNAEY08633 homozygous mutants exhibit a significant defect in growth compared to control strains, beginning 3 days after egg deposition. At 5 days after egg deposition the mean cross-sectional area of homozygous RNaseMRP:RNAEY08633 is approximately one-third that of controls. Homozygous RNaseMRP:RNAEY08633 mutants are also delayed in development, undergoing the first moult approximately 1 day later than normal.

        Despite the defects in growth and delayed development, RNaseMRP:RNAEY08633 mutants show no gross physical deformities.

        Homozygous RNaseMRP:RNAEY08633 mutants show a bimodal pattern of mortality, with approximately 70% of individuals dying between 5 and 6 days of age while the remaining individuals linger as second instar larvae for up to 17 days after egg deposition, which is several days after normal individuals have reached adulthood. Mouth hooks examined after death have two to four teeth, characteristic of the second instar stage.

        RNaseMRP:RNAEY08633 mutants show impaired rRNA processing.

        (Schneider et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        RNaseMRP:RNAEY08633
        dMRP:RNAEY08633
        (Schneider et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)