FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mettl3c2
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General Information
Symbol
Dmel\Mettl3c2
Species
D. melanogaster
Name
FlyBase ID
FBal0265684
Feature type
allele
Associated gene
Dmel\Mettl3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Hongay and Orr-Weaver, 2011)
Mutagen
P-element activity
(Hongay and Orr-Weaver, 2011)
Progenitor genotype
P{SUPor-P}PacsKG02054
(Hongay and Orr-Weaver, 2011)
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,031,496..24,031,607 [+]
Comment:

Small deletion upstream of Mettl3 that result in a hypomorphic allele with lower levels of Mettl3 mRNA. Extent of deletion determined from provided sequences in Fig. S1.

(Hongay and Orr-Weaver, 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Viable homozygous Ime4c2 adults are recovered at much lower than expected Mendelian frequencies and are significantly subfertile. Non-viable homozygotes die at larval and pupal stages.

      (Hongay and Orr-Weaver, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ime4c2
      Mettl3c2
      ime4c2
      (Hongay and Orr-Weaver, 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)