FB2026_02 , released June 18, 2026
Allele: Dmel\GlcAT-Pbrv2
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General Information
Symbol
Dmel\GlcAT-Pbrv2
Species
D. melanogaster
Name
brave2
FlyBase ID
FBal0265806
Feature type
allele
Associated gene
Dmel\GlcAT-P
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pandey et al., 2011)
Progenitor genotype
Cytology
Description

A G to A transition leads to a premature stop codon at the 10th amino acid of the 7th exon of GlcAT-P.

(Pandey et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:11,178,910..11,178,910 [-]
Nucleotide change:

G11178910A

Reported nucleotide change:

G?A

Amino acid change:

W355term | GlcAT-P-PA; W192term | GlcAT-P-PB; W192term | GlcAT-P-PC; W355term | GlcAT-P-PD; W192term | GlcAT-P-PE

Reported amino acid change:

W?term

Comment:

TGG to TAG nonsense mutation in a Trp codon. See also Figure S1.

(Pandey et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GlcAT-Pbrv2 mutant 3rd instar larvae exhibit a dramatically extended larval ventral nerve cord, 2-3 times that found in wild-type controls.

      GlcAT-Pbrv2 adult escapers show developmental defects in the legs, while some exhibit rudimentary wings.

      (Pandey et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      GlcAT-Pbrv2 is rescued by GlcAT-PCH322-82E19

      (Pandey et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GlcAT-Pbrv2
      brv2
      (Pandey et al., 2011)
      Name Synonyms
      brave2
      (Pandey et al., 2011)
      Secondary FlyBase IDs
        References (1)