FlyBase Allele Report: Dmel\vari[RNAi.UAS.cBa]

General Information

Symbol

Dmel\vari^RNAi.UAS.cBa

Species

D. melanogaster

Name

FlyBase ID

FBal0266078

Feature type

allele

Associated gene

Dmel\vari

Associated Insertion(s)

Carried in Construct

P{UAS-vari.RNAi.B}

Key Links

Transgenic product class

RNAi_reagent

(Bachmann et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Bachmann et al., 2008)

Mutagen

in vitro construct

(Bachmann et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-vari.RNAi.B}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat which covers part of the SH3 and the complete GUK domain of vari.

(Bachmann et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

vari

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage, with Scer\GAL4^sd-SG29.1

(Bachmann et al., 2008)

some die during pharate adult stage, with Scer\GAL4^sd-SG29.1

(Bachmann et al., 2008)

visible, with Scer\GAL4^ey.PH

(Bachmann et al., 2008)

visible, with Scer\GAL4^sd-SG29.1

(Bachmann et al., 2008)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Bachmann et al., 2008)

ocellus, with Scer\GAL4^ey.PH

(Bachmann et al., 2008)

wing, with Scer\GAL4^sd-SG29.1

(Bachmann et al., 2008)

wing margin, with Scer\GAL4^sd-SG29.1

(Bachmann et al., 2008)

Detailed Description

Statement

Reference

Expression of vari^{dsRNA.Scer\UAS.cBa} under the control of Scer\GAL4^sd-SG29.1 results in either adult flies with defective wings (having gaps in the wing margin and defects in wing unfolding) or pharate adults, depending on the vari^{dsRNA.Scer\UAS.cBa} line used.

Expression of vari^{dsRNA.Scer\UAS.cBa} under the control of Scer\GAL4^ey.PH results in defects in the eye, including roughening, malformations and a reduction in size. However, the photoreceptor cells do not show major morphogenetic defects and are still organised in a trapezoid pattern as in wild type. In some cases, the eye tissue is replaced by head cuticle. The flies also show a partial or total loss of the ocelli.

(Bachmann et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99592

w^*; P{UAS-vari.RNAi.B}4.4

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

vari^RNAi.UAS.cBa

vari^{dsRNA.Scer\UAS.cBa}

vari^{dsRNA.UAS.cBa}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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