FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\boiC1
Open Close
General Information
Symbol
Dmel\boiC1
Species
D. melanogaster
Name
FlyBase ID
FBal0266140
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

Amino acid replacement: W626term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G2447117A

Reported nucleotide change:

G?A

Amino acid change:

W175term | boi-PA; W626term | boi-PB; W626term | boi-PE; W626term | boi-PF; W626term | boi-PG

Reported amino acid change:

W626term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The presence of boiC1 in 'cis' with boiEP1447 suppresses the ectopic wing veins caused by expression of boiEP1447 under the control of Scer\GAL4ap-md544.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

boiC1 is a suppressor of viable phenotype of ihogDC1

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Larvae that are double mutant for ihogDC1 and boiC1 die 24 to 48 hours after hatching and never reach third instar (L3).

The viability of boiC1; ihogDC1 double mutants is rescued by the basal level of expression of ihogScer\UAS.T:Hsap\MYC in the absence of any Scer\GAL4 driver.

In boiC1 hemizygotes, eye development is severely compromised in the presence of mitotic clones of cells mutant for ihogDC1/ihogDC1 leading to structural defects. Photoreceptor cell differentiation is impaired in the mutant cells.

The eye morphology in ihogDC1 mosaics in boiC1 hemizygotes is rescued by the basal level of expression of ihogScer\UAS.T:Hsap\MYC in the absence of any Scer\GAL4 driver.

In contrast to control clones, double mutant clones (homozygous ihogDC1 clones in boiC1 hemizygotes) in third instar wing imaginal discs often straddle the anterior-posterior boundary and form tight borders with both anterior and posterior cells. This modified segregation behaviour indicates that anterior cells lacking both ihog and boi sort out from the anterior compartment into posterior territory. However, similarly to wild-type cells, double mutant posterior clones of homozygous ihogDC1 mutant cells in boiC1 hemizygotes do respect the compartment boundary and do not sort into anterior territory.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)