FB2026_02 , released June 18, 2026
Allele: Dmel\Atox1174
Open Close
General Information
Symbol
Dmel\Atox1174
Species
D. melanogaster
Name
FlyBase ID
FBal0266145
Feature type
allele
Associated gene
Dmel\Atox1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Hua et al., 2011)
    Mutagen
    Progenitor genotype
    P{EPgy2}Atox1EY15780
    (Hua et al., 2011)
    Cytology
    Description

    Imprecise excision of P{EPgy2}Atox1EY15780 resulting in a 450 base pair deletion removing the first two of the three exons of Atox1.

    (Hua et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3L:21,641,011..21,641,460 [+]
    Comment:

    A 450 bp deletion resulting from the imprecise excision of P{EPgy2}Atox1EY15780 which starts at the insertion site and removes the first two exons of Atox1.

    (Hua et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Atox1174 mutants are viable and fertile under standard laboratory conditions, although their survival rate during development is reduced. The most obvious phenotype of Atox1174 mutants is that they can not tolerate copper starvation under conditions which pose no problem for wild-type flies.

        Compared with wild-type flies, Atox1174 mutants are less sensitive to the toxicity of the anticancer drug cisplatin (cis-diammineplatinum(II) dichloride).

        (Hua et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Atox1174
        (Hua et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)