FlyBase Allele Report: Dmel\EDTP[HMS01577]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\EDTP^HMS01577

General Information

Symbol

Dmel\EDTP^HMS01577

Species

D. melanogaster

Name

FlyBase ID

FBal0266484

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01577}

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01577}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q72.ex1p.UAS.EGFP}

(Xiao and Qiu, 2019)

modeled by Hsap\HTT^{Q103.ex1p.UAS.EGFP}

(Xiao et al., 2019)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^1-42.UAS

(Xiao et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

long lived, with Scer\GAL4^Toll-6-D42

(Xiao et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Females heterozygous for EDTP^HMS01577 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to EDTP^HMS01577 males results in: 45% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

EDTP^HMS01577, Scer\GAL4^Toll-6-D42 is a suppressor of short lived phenotype of Hsap\APP^1-42.UAS, Scer\GAL4^Toll-6-D42

(Xiao et al., 2019)

EDTP^HMS01577, Scer\GAL4^Toll-6-D42 is a suppressor | partially of short lived phenotype of Hsap\HTT^{Q103.ex1p.UAS.EGFP}, Scer\GAL4^Toll-6-D42

(Xiao et al., 2019)

Other

Statement

Reference

EDTP^HMS01577, Hsap\APP^1-42.UAS, Scer\GAL4^Toll-6-D42 has long lived phenotype

(Xiao et al., 2019)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EDTP^HMS01577

(Manzéger et al., 2021)

EDTP^TRiP(V20)

(Manzéger et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections