Expression of Nf1^Scer\UAS.cTa under the control of Scer\GAL4^arm.PS results in a mean life span increase of 74% in males and 81% in females and an increase in maximal life span of 65% in males and 70% in females, relative to controls.

Both male and female flies expressing Nf1^Scer\UAS.cTa under the control of Scer\GAL4^elav-C155 show a life span extension of approximately 50%.

Mitochondria NADH-linked (pyruvate+malate) respiration rates from flies expressing Nf1^Scer\UAS.cTa under the control of Scer\GAL4^arm.PS are 25%-38% higher than those of controls, in the presence of ADP, but not in the absence of ADP. In contrast, the respiration rates recorded when using the FADH[[2]]-linked complex II substrate succinate are essentially the same as in controls, with or without ADP.

Complex I activity is 38% higher in flies expressing Nf1^Scer\UAS.cTa under the control of Scer\GAL4^arm.PS compared to controls.

Mitochondrial H[[2]]O[[2]] production is reduced by 58-59% in flies expressing Nf1^Scer\UAS.cTa under the control of Scer\GAL4^arm.PS, compared to control flies. This reduced mitochondrial ROS is also associated with increased mitochondrial aconitase activity throughout life.