FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Apc2WT.EGFP
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General Information
Symbol
Dmel\Apc2WT.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0267816
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
PBac{Apc2-EGFP.WT}
Also Known As
GFP-APC2, WT APC2
Key Links
Transgenic product class
wild_type
(Roberts et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Roberts et al., 2011)
Mutagen
in vitro construct
(Roberts et al., 2012, Roberts et al., 2011)
Progenitor genotype
Carried in construct
PBac{Apc2-EGFP.WT}
Cytology
Description

The endogenous Apc2 promoter drives expression of full length, wild-type Apc2 which is tagged at the N-terminal end with EGFP.

(Roberts et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Apc2WT.EGFP is a suppressor of lethal - all die during embryonic stage phenotype of Apc2g10, ApcQ8

      (Yamulla et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Apc2WT.EGFP is a suppressor of embryonic/larval cuticle | embryonic stage phenotype of Apc2g10, ApcQ8

      (Roberts et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Apc2WT.T:Avic\GFP-EGFP suppresses the embryonic lethality and cuticle patterning defects seen in maternally and zygotically Apc2g10 ApcQ8 double mutant embryos.

      (Yamulla et al., 2014)

      Expression of Apc2T:Avic\GFP-EGFP rescues the anterior fate loss seen in Apc2g10 ApcQ8 maternal/zygotic mutant embryos.

      (Roberts et al., 2012)

      Apc2WT.T:Avic\GFP-EGFP rescues the cuticle defects and lethality of embryos derived from Apc2g10 ApcQ8 males crossed to females containing double homozygous germline clones.

      (Roberts et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The embryonic lethality along with the cuticle defects (loss of denticles, expansion of naked cuticle) characteristic for maternal/zygotic Apc2g10,ApcQ8 mutants is rescued by combination with either Apc2WT.T:Avic\GFP-EGFP or Apc2DD. In contrast, Apc2AA only slightly improves embryonic viability od the mutants and largely fails to rescue the cuticle phenotypes too.

      (Pronobis et al., 2015)

      Expression of Apc2WT.T:Avic\GFP-EGFP rescues the embryonic lethality and cuticle patterning defects seen in maternally and zygotically Apc2g10 mutant embryos. The rescued stock is adult viable.

      (Yamulla et al., 2014)

      Expression of Apc2T:Avic\GFP-EGFP rescues the loss of anterior fates seen in maternal/zygotic Apc2g10 mutant embryos.

      (Roberts et al., 2012)

      Apc2WT.T:Avic\GFP-EGFP rescues the cuticle defects of embryos lacking both maternal and zygotic Apc2[+] function (homozygous Apc2g10 embryos derived from Apc2g10 females). The embryonic lethality of these Apc2 mutants is also rescued, to adult viability.

      (Roberts et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Apc2T:Avic\GFP-EGFP
      Apc2WT.EGFP
      Apc2WT.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (7)