FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GstO21
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General Information
Symbol
Dmel\GstO21
Species
D. melanogaster
Name
FlyBase ID
FBal0267935
Feature type
allele
Associated gene
Dmel\GstO2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kim et al., 2012)
Mutagen
P-element activity
(Kim et al., 2012)
Progenitor genotype
Cytology
Description

Imprecise excision of P{EP}GE26508 results in removal of the CG6673 coding region.

(Kim et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GstO21 mutants exhibit no obvious defects in adult morphology.

      The dehydroascorbate reductase (DHAR) activity in GstO21 flies is dramatically decreased to 5% of the DHAR activity found in wild-type flies.

      GstO21 mutants are sensitive to paraquat.

      GstO21 mutants show a normal muscle phenotype.

      (Kim et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      GstO21 is an enhancer of abnormal neuroanatomy phenotype of park1

      (Kim et al., 2012)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      GstO21 is an enhancer of indirect flight muscle cell phenotype of park1

      (Kim et al., 2012)

      GstO21 is an enhancer of dopaminergic PPL1 neuron phenotype of park1

      (Kim et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      GstO21/park1 double mutants show dramatically enhanced degeneration of the indirect flight muscles compared with park1 single mutants.

      20-day-old park1/GstO21 double mutants show significantly increased DA neuron degeneration in the PPL1 cluster compared to park1 single mutants of the same age, whereas there is no difference in neuronal degeneration between park1/GstO21 double mutants and park1 single mutants in 1-day-old flies.

      (Kim et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      GstO21 is rescued by GstO2A.UAS/Scer\GAL4αTub84B.PL

      (Kim et al., 2012)

      GstO21 is rescued by GstO2B.UAS/Scer\GAL4αTub84B.PL

      (Kim et al., 2012)
      Comments

      Paraquat sensitivity in GstO21 mutants is rescued through Scer\GAL4αTub84B.PL-driven expression of GstO2B.Scer\UAS or (to a lesser extent) GstO2A.Scer\UAS.

      (Kim et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG66731
      DmGstO1null
      (Kim et al., 2012)
      GstO11
      GstO1null
      (Kim et al., 2012)
      GstO21
      Name Synonyms
      Secondary FlyBase IDs
        References (1)