FlyBase Allele Report: Dmel\Gr8a[1]

General Information

Symbol

Dmel\Gr8a¹

Species

D. melanogaster

Name

FlyBase ID

FBal0268060

Feature type

allele

Associated gene

Dmel\Gr8a

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Lee et al., 2012)

Progenitor genotype

P{EP}Gr8a^G17495

(Lee et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 934bp deletion which removes sequences encoding amino acid residues 15-305.

(Lee et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:9,227,337..9,228,270 [+]

Comment:

934 bp deletion resulting from the imprecise excision of P{EP}Gr8a^G17495, which removes aa 15-305.

(Lee et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior

(Lee et al., 2012)

abnormal neurophysiology | adult stage

(Lee et al., 2012)

fertile

(Lee et al., 2012)

viable

(Lee et al., 2012)

Phenotype Manifest In

short labellar taste bristle S-a

(Lee et al., 2012)

short labellar taste bristle S-b

(Lee et al., 2012)

Detailed Description

Statement

Reference

Gr8a¹ mutant flies do not show significant changes in the expected avoidance response to food laced with acetic acid (5%), as compared to controls.

(Rimal et al., 2019)

Gr8a¹ mutant adults show normal avoidance of umbelliferone in a two-way choice feeding assay.

(Poudel et al., 2015)

Mutant flies display severely impaired L-canavanine avoidance in a two-way choice test.

L-canavanine-induced action potentials are eliminated in the S3, S5 and S10 taste sensilla of mutant flies. The S3, S5 and S10 taste sensilla of mutant flies show a normal electrophysiological response to L-arginine.

Mutant flies show normal behavioural and electrophysiological responses to the following repulsive tastants: caffeine, quinine, berberine, denatonium, lobeline, papaverine, strychnine and DEET.

(Lee et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Gr8a¹ is rescued by Scer\GAL4^Gr8a.0.7/Gr8a^UAS.cLa

(Lee et al., 2012)

Gr8a¹ is rescued by Scer\GAL4^Gr66a.PD/Gr8a^UAS.cLa

(Lee et al., 2012)

Comments

Expression of Gr8a^Scer\UAS.cLa under the control of either Scer\GAL4^Gr66a.PD or Scer\GAL4^Gr8a.0.7 rescues a normal avoidance response to L-canavanine in Gr8a¹ flies.

Expression of Gr8a^Scer\UAS.cLa under the control of either Scer\GAL4^Gr66a.PD or Scer\GAL4^Gr8a.0.7 restores normal L-canavanine-induced action potentials in the S3, S5 and S10 taste sensilla of Gr8a¹ flies.

(Lee et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

40976

w^* Gr8a¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Gr8a¹

(Guillemin et al., 2025, Vernier et al., 2023, Dhakal et al., 2021, Rimal and Lee, 2019, Rimal et al., 2019, Sang et al., 2019, Lee et al., 2018, Poudel et al., 2017, Poudel et al., 2015, Lee et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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