FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eaterunspecified
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General Information
Symbol
Dmel\eaterunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0268197
Feature type
allele
Associated gene
Dmel\eater
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  bacterial infectious disease
        CEA
        (Christofi and Apidianakis, 2013)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant eaterunspecified flies exhibit increased susceptibility to P. aeruginosa infection compared to wild-type flies.

        Mutant eaterunspecified flies exposed to non-replicating P. aeruginosa flies survive longer than non-primed eaterunspecified flies. Five days after exposure, eaterunspecified flies exhibit the same susceptibility to infection as non-primed flies, while wild-type flies are still significantly protected by priming, indicating that immune priming may be dependent on phagocytosis.

        (Christofi and Apidianakis, 2013)

        Larval hemocytes prepared from flies lacking eater expression less effectively phagocytose the parental S. aureus strain, compared with hemocytes of wild type flies. As for wild type, phagocytosis of the mutant 'ItaS' S. aureus strain by eater-deficient hemocytes is decreased compared to phagocytosis of the parental strain.

        (Hashimoto et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        eaterunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)